The episcopate of Ambrose of Milan (374-97 CE) is crucial to understanding the developing relationship between the Church and the Roman Empire in late antiquity. As bishop of Milan, Ambrose clashed frequently with the highest levels of imperial authority, in large part due to his ardent belief that he should be free to govern his church without imperial interference.

This collection of Ambrose's writings comprises the tenth volume of his published collection of letters as well as extant uncollected letters and funeral orations for emperors Valentinian II and Theodosius I.